1380 PPAR-γ modulation as a novel therapeutic strategy for scarring alopecia
نویسندگان
چکیده
منابع مشابه
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The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-gamma agonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple ...
متن کاملPPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed in human sebaceous glands. Disruption of PPAR-γ is believed to be one of the mechanisms of primar...
متن کاملPsoriatic scarring alopecia*
Psoriasis is a relatively frequent inflammatory dermatosis. Scarring alopecia due to scalp psoriasis was first reported in 1972, but few reports have been written since then, showing that this is a very rare complication of a common disorder. We report a young Brazilian woman with longstanding scalp psoriasis, which progressed to scaring alopecia.
متن کاملNovel Therapeutic Agents in Pediatric Sepsis: Peroxisome Proliferator Receptor γ (PPAR γ) Agonists.
Sepsis is characterized by a systemic inflammatory response. Systemic physiologic changes can occur and lead to cellular damage and organ failure. The nuclear receptor, peroxisome proliferator-activated receptor(PPAR ), is involved in the regulation of the inflammatory response and is altered in sepsis. Thiazolidinediones (TZDs), and the cyclopentenone prostaglandin, 15d-PGJ2, are specific PPAR...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.1397